Project information
Uplatnění multiparametrické průtokové cytometrie ve studiu patofyziologie maligních plazmatických buněk
- Project Identification
- GP301/09/P457
- Project Period
- 3/2009 - 12/2011
- Investor / Pogramme / Project type
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Czech Science Foundation
- Postdoctoral projects
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- monoclonal gammopathy; multiple myeloma; plasma cells; flow cytometry
Immunophenotypisation of plasma cells using multiparametric flow cytometry brings enough data to define and distinguish heterogeneous population of neoplastic plasma cells from their normal equivalent. The aim of this project is to identify phenotypic profile in subjects with monoclonal gammopathy. The pathophysiology of plasma cells and changes in their behavior will be studied on cellular and molecular level to detect possible relationship between these changes and possibility of malignant transformation in monoclonal gammopathy of
undetermined significance. This project can be used to identify new predictive and prognostic markers. They could lead to definite determination of diagnose, assessment of risk of progression in asymptomatic monoclonal gammopathies with consequent well-timed and accurately targeted treatment. The markers also
could help to evaluate minimal residual disease and efficacy of treatment.
Publications
Total number of publications: 31
2012
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Analýza moderních prognostických faktorů na buněčné a molekulární úrovni určujících riziko transformace monoklonální gamapatie nejasného významu do mnohočetného myelomu
Klinická biochemie a metabolismus, year: 2012, volume: 20(41), edition: 2
2011
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Advanced 8-colour flow cytometry in analysis of monoclonal gammopathies
Year: 2011, type: Conference abstract
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Analýza fenotypu plazmocytů a korelace s cytogenetickými a morfologickými nálezy u mnohočetného myelomu
Year: 2011, type: Conference abstract
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Analýza klonality u monoklonálních gamapatií s využitím 8-barevné průtokové cytometrie
Year: 2011, type: Conference abstract
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Clonality assessment in monoclonal gammopathies
Year: 2011, type: Conference abstract
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Clonality assessment using 8-color flow cytometry
Year: 2011, type: Conference abstract
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Correlation of plasma cell phenotype with cytogenetic and morphological findings in multiple myeloma
Year: 2011, type: Conference abstract
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Flow Cytometry in Monoclonal Gammopathies
Klinická onkologie, year: 2011, volume: 24, edition: Suppl.
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Monitoring of minimal residual disease in multiple myeloma patients: Development and standardization of method.
Year: 2011, type: Conference abstract
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Plasma cell phenotype correlation with cytogenetic and morphological findings in multiple myeloma
Year: 2011, type: Conference abstract