Project information
Myb, Fos, Jun and retinoid receptor protein interactions in anti-leukemic processes
- Project Identification
- GA312/98/0679
- Project Period
- 1/1998 - 1/2000
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Malignant transformation results from a genetical changes interfering with a complex signal network, which in healthy cells controls processes of diferentiation, proliferation and death to maintain homeostasis. Understanding of the role of key regulators in this network and their interactions is an important step in creation of powerful anti-tumor therapies. Proteins Myb, Jun, Fos a retinoid receptors belong to this group and we wish to determine the role they play in regulation of differentiation and p roliferation of leukemic cells. The project is designed to get information on anti-tumor activities of varios retinoids in leukemic cells, on the effects of Myb, RAR and RXR protein interactions for their DNA-binding - and transactivation abilities, on t he genes which are controled by retinoid receptors and mediate the function of retinoid ligands. In addition the project includes the methods to explore the function of Fos and Jun proteins in regulation of hematopoietic differentiation and their interac
Publications
Total number of publications: 15
2001
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Odlišné účinky virové a buněčné formy proteinu Jun na monoblasty transformované onkogenem v-myb
V. pracovní setkání biochemiků a molekulárních biologů, year: 2001
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Onkogen v-myb a možnosti jeho suprese
Scripta medica, year: 2001, volume: 74, edition: 2
2000
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c-Jun is essential for differentiation of v-myb-transformed monoblasts induced by TPA.
The 16th Annual Meeting on Oncogenes, year: 2000
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Partial v-Myb suppression by Fos and Jun proteins
Cells II, edition: Vyd. první, year: 2000, number of pages: 1 s.
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Srovnání anti-onkogenních vlastností retinoidových receptorů RAR a RXR.
Biochemistry and molecular biology on the threshold of a new century, year: 2000
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The effects of RARa and RXRa proteins on growth, viability and differentiation of v-myb-transformed monoblasts
Blood Cells, Molecules and Diseases, year: 2000, volume: 26, edition: 4
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The role of the fos and jun oncogenes in the myeloid differentiation pathway.
Biochemistry and molecular biology on the threshold of a new century, year: 2000
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Význam specifity ligandu pro protinádorové účinky retinoidových receptorů.
Biochemistry and molecular biology on the threshold of a new century, year: 2000
1999
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Activated retinoid receptors suppress the v-myb oncogene
Cells, year: 1999, number of pages: 1 s.
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Differential effects of Fos and Jun proteins on v-myb-transformed monoblasts
The 15th Annual Meeting on Oncogenes, year: 1999