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Project information
Classification of brain tumors using advanced techniques of multimodal diffusion MRI data

Project Identification
NU21-08-00359
Project Period
5/2021 - 12/2024
Investor / Pogramme / Project type
Ministry of Health of the CR
  • Ministry of Health Research Programme 2020 - 2026
  • Subprogram 1 - standard
MU Faculty or unit
Faculty of Informatics
Cooperating Organization
University Hospital Brno-Bohunice
  • Responsible person doc. MUDr. Miloš Keřkovský, Ph.D.

Brain tumours comprise a relatively rare disease, but one that is a significant cause of morbidity and mortality. Diagnosis of brain tumours, which is based mainly on magnetic resonance imaging (MRI), is crucial for choosing optimal treatment strategies. In many cases, however, MRI provides non-specific findings and differentiation of individual types of tumours may be problematic using conventional MRI methods. In recent years, various MRI diffusion imaging techniques have been introduced that, in conjunction with advanced data analysis, have the potential to upgrade the possibilities for non-invasive classification of brain tumours. The main goal of this project will be to develop automated methodological procedures enabling the differentiation of individual types of brain tumours based on multimodal MRI data. The prospective study will include about 240 patients with brain tumours who will undergo MRI of the brain and subsequent resection or stereotactic biopsy of the pathological brain lesion. The MRI protocol will include diffusion tensor imaging (DTI) and intra-voxel incoherent motion (IVIM) techniques. Using machine-learning methods, automated techniques of MRI images segmentation will be developed together with advanced classification algorithms enabling differentiation of individual tumour types based on their morphological and diffusion features. The accuracy of the stated procedures in the matter of differentiating individual types of tumours will be verified in correlation with histopathological findings.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 9 – Industry, innovation and infrastructure

Publications

Total number of publications: 5

2024

2023

2022

  • Differentiation of high grade glioma and brain metastasis using intravoxel incoherent motion MRI

    KEŘKOVSKÝ Miloš DOSTÁL Marek KOPŘIVOVÁ Tereza JŮZA Tomáš VYBÍHAL Václav NEUMAN Eduard MATULA Petr KOZUBEK Michal

    Appeared in Conference without Proceedings

    Year: 2022, type: Appeared in Conference without Proceedings

  • Federated learning enables big data for rare cancer boundary detection

    PATI Sarthak BAID Ujjwal EDWARDS Brandon SHELLER Micah WANG Shih-Han REINA G Anthony FOLEY Patrick GRUZDEV Alexey KARKADA Deepthi DAVATZIKOS Christos SAKO Chiharu GHODASARA Satyam BILELLO Michel MOHAN Suyash VOLLMUTH Philipp BRUGNARA Gianluca PREETHA Chandrakanth J SAHM Felix MAIER-HEIN Klaus ZENK Maximilian BENDSZUS Martin WICK Wolfgang CALABRESE Evan RUDIE Jeffrey VILLANUEVA-MEYER Javier CHA Soonmee INGALHALIKAR Madhura JADHAV Manali PANDEY Umang SAINI Jitender GARRETT John LARSON Matthew JERAJ Robert CURRIE Stuart FROOD Russell FATANIA Kavi HUANG Raymond Y CHANG Ken QUINTERO Carmen Balana CAPELLADES Jaume PUIG Josep TRENKLER Johannes PICHLER Josef NECKER Georg HAUNSCHMIDT Andreas MECKEL Stephan SHUKLA Gaurav LIEM Spencer ALEXANDER Gregory S LOMBARDO Joseph PALMER Joshua D FLANDERS Adam E DICKER Adam P SAIR Haris I JONES Craig K VENKATARAMAN Archana JIANG Meirui SO Tiffany Y CHEN Cheng HENG Pheng Ann DOU Qi KOZUBEK Michal LUX Filip MICHÁLEK Jan MATULA Petr KEŘKOVSKÝ Miloš KOPŘIVOVÁ Tereza DOSTÁL Marek VYBÍHAL Václav VOGELBAUM Michael A MITCHELL J Ross FARINHAS Joaquim MALDJIAN Joseph A YOGANANDA Chandan Ganesh Bangalore PINHO Marco C REDDY Divya HOLCOMB James WAGNER Benjamin C ELLINGSON Benjamin M CLOUGHESY Timothy F RAYMOND Catalina OUGHOURLIAN Talia HAGIWARA Akifumi WANG Chencai TO Minh-Son BHARDWAJ Sargam CHONG Chee AGZARIAN Marc FALCAO Alexandre Xavier MARTINS Samuel B TEIXEIRA Bernardo C A SPRENGER Flávia MENOTTI David LUCIO Diego R LAMONTAGNE Pamela MARCUS Daniel WIESTLER Benedikt KOFLER Florian EZHOV Ivan METZ Marie JAIN Rajan LEE Matthew LUI Yvonne W MCKINLEY Richard SLOTBOOM Johannes RADOJEWSKI Piotr MEIER Raphael WIEST Roland MURCIA Derrick FU Eric HAAS Rourke THOMPSON John ORMOND David Ryan BADVE Chaitra SLOAN Andrew E VADMAL Vachan WAITE Kristin COLEN Rivka R PEI Linmin AK Murat SRINIVASAN Ashok BAPURAJ J Rajiv RAO Arvind WANG Nicholas YOSHIAKI Ota MORITANI Toshio TURK Sevcan LEE Joonsang PRABHUDESAI Snehal MORÓN Fanny MANDEL Jacob KAMNITSAS Konstantinos GLOCKER Ben DIXON Luke V M WILLIAMS Matthew ZAMPAKIS Peter PANAGIOTOPOULOS Vasileios TSIGANOS Panagiotis ALEXIOU Sotiris HALIASSOS Ilias ZACHARAKI Evangelia I MOUSTAKAS Konstantinos KALOGEROPOULOU Christina KARDAMAKIS Dimitrios M CHOI Yoon Seong LEE Seung-Koo CHANG Jong Hee AHN Sung Soo LUO Bing POISSON Laila WEN Ning TIWARI Pallavi VERMA Ruchika BAREJA Rohan YADAV Ipsa CHEN Jonathan KUMAR Neeraj SMITS Marion VAN DER VOORT Sebastian R ALAFANDI Ahmed INCEKARA Fatih WIJNENGA Maarten M J KAPSAS Georgios GAHRMANN Renske SCHOUTEN Joost W DUBBINK Hendrikus J VINCENT Arnaud J P E VAN DEN BENT Martin J FRENCH Pim J KLEIN Stefan YUAN Yading SHARMA Sonam TSENG Tzu-Chi ADABI Saba NICLOU Simone P KEUNEN Olivier HAU Ann-Christin VALLIERES Martin FORTIN David LEPAGE Martin LANDMAN Bennett RAMADASS Karthik XU Kaiwen CHOTAI Silky CHAMBLESS Lola B MISTRY Akshitkumar THOMPSON Reid C GUSEV Yuriy BHUVANESHWAR Krithika SAYAH Anousheh BENCHEQROUN Camelia BELOUALI Anas MADHAVAN Subha BOOTH Thomas C CHELLIAH Alysha MODAT Marc SHUAIB Haris DRAGOS Carmen ABAYAZEED Aly KOLODZIEJ Kenneth HILL Michael ABBASSY Ahmed GAMAL Shady MEKHAIMAR Mahmoud QAYATI Mohamed REYES Mauricio PARK Ji Eun YUN Jihye KIM Ho Sung MAHAJAN Abhishek MUZI Mark BENSON Sean BEETS-TAN Regina G H TEUWEN Jonas HERRERA-TRUJILLO Alejandro TRUJILLO Maria ESCOBAR William ABELLO Ana BERNAL Jose GÓMEZ Jhon CHOI Joseph BAEK Stephen KIM Yusung ISMAEL Heba ALLEN Bryan BUATTI John M KOTROTSOU Aikaterini LI Hongwei WEISS Tobias WELLER Michael BINK Andrea POUYMAYOU Bertrand SHAYKH Hassan F SALTZ Joel PRASANNA Prateek SHRESTHA Sampurna MANI Kartik M PAYNE David KURC Tahsin PELAEZ Enrique FRANCO-MALDONADO Heydy LOAYZA Francis QUEVEDO Sebastian GUEVARA Pamela TORCHE Esteban MENDOZA Cristobal FRANCO Vera RÍOS Elvis LÓPEZ Eduardo VELASTIN Sergio A OGBOLE Godwin SONEYE Mayowa OYEKUNLE Dotun ODAFE-OYIBOTHA Olubunmi OSOBU Babatunde SHU'AIBU Mustapha DORCAS Adeleye DAKO Farouk SIMPSON Amber L HAMGHALAM Mohammad PEOPLES Jacob J HU Ricky TRAN Anh CUTLER Danielle MORAES Fabio Y BOSS Michael A GIMPEL James VEETTIL Deepak Kattil SCHMIDT Kendall BIALECKI Brian MARELLA Sailaja PRICE Cynthia CIMINO Lisa APGAR Charles SHAH Prashant MENZE Bjoern BARNHOLTZ-SLOAN Jill S MARTIN Jason BAKAS Spyridon

    Article in Periodical

    Nature Communications, year: 2022, volume: 13, edition: 7346, DOI

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