Project information
Mechanorecepce jako mechanizmus řídící odontogenezi napříč obratlovci
- Project Identification
- GA22-02794S
- Project Period
- 1/2022 - 12/2024
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
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Faculty of Medicine
- doc. Mgr. Jan Křivánek, Ph.D.
- Klára Cigošová
- Marcos González López, MSc.
- Bc. Margarita Gorbulina
- Ema Grofová
- doc. Ing. Petr Henyš, Ph.D.
- Adéla Kadlecová
- Magdaléna Koloušková
- Mgr. Josef Lavický
- Cooperating Organization
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Institute of Animal Physiology and Genetics of thr ASCR, v. v. i.
- Responsible person doc. RNDr. Marcela Buchtová, Ph.D.
Tooth development is precisely controlled system with the involvement of different pools of stem cell niches. However, the cellular mechanisms underlaying tooth growth and dental tissue repair still remain to be elusive. The main aim of this project is to determine the role of cellular mechanosensing and associated signalling in regulation of tooth growth and the contribution of these processes in the healing of dental tissues. Rodent incisors and their tooth-bone interphase area will be used as a model to study permanent grow activity and mouse molars will serves as a model of soft tissue damage leading to ankylosis. Moreover, comparison with other vertebrate species will help us to uncover if mechanosensing is a general mechanism used by all vertebrates regardless on morphology of tooth-bone area during odontogenesis. This project will help us also to understand mechanisms involved in reparative and regenerative odontogenesis and to tack more general questions extending beyond the dental field, which will provide new insight to the regulation of developmental and healing processes.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 6
2024
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Unveiling vertebrate development dynamics in frog Xenopus laevis using micro-CT imaging
GigaScience, year: 2024, volume: 13, edition: JUNE, DOI
2023
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A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
Nature Communications, year: 2023, volume: 14, edition: 1, DOI
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Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue
Scientific Reports, year: 2023, volume: 13, edition: 1, DOI
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Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development
Science Advances, year: 2023, volume: 9, edition: 31, DOI
2022
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Mouse molar development and the role of mechanosensation in the root formation
Year: 2022, type: Conference abstract
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Revealing the complexity of mesenchymal stem cell niche of continuously growing teeth
Year: 2022, type: Conference abstract