Publication details

Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis

Investor logo
Authors

BENEŠOVÁ Yvonne VAŠKŮ Anna ŠTOURAČ Pavel HLADÍKOVÁ Magdaléna FIALA Adam BEDNAŘÍK Josef

Year of publication 2013
Type Article in Periodical
Magazine / Source Journal of Neuroimmunology
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.sciencedirect.com/science/article/pii/S0165572812003177
Doi http://dx.doi.org/10.1016/j.jneuroim.2012.10.014
Field Neurology, neurosurgery, neurosciences
Keywords Gene; HLA-DRB1*1501; Multiple sclerosis; Tagging polymorphism
Attached files
Description We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info