Publication details
Barrettův jícen, rizikové faktory, léčba
| Title in English | Barrett's esophagus, risk factors and management |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Interní medicina pro praxi |
| MU Faculty or unit | |
| Citation | |
| web | http://www.internimedicina.cz/pdfs/int/2012/03/04.pdf |
| Field | Other specializations of internal medicine |
| Keywords | gastroesophageal reflux disease; Barrett's esofagus; premalignant; proton pump inhibitors; fundoplication; endoscopic therapy |
| Description | Barrett's esophagus (BE) is a premalignant lesion developed due to chronic gastroesophageal reflux. The squamous esophageal mucosa is replaced by columnar epithelium. The squamocolumnar junction is displaced proximally and metaplastic epithelium should be confirmed from biopsy samples. The risk of development of adenocarcinoma is 30–40 times higher in patiens with BE than in patients without this condition. Incidence of cancer in patients with BE is approximatelly 0,2–0,5 % per year. Endoscopic surveillance program has been established to diagnose early dysplasia and cancer. Antireflux therapy by acid suppressant drugs or surgery is an important part of management. Guidelines for the surveillance and management have been published. High grade dysplasia and early adenocarcinoma can be succesfully treated endoscopically. The surgical resection as an alternative option. |