Publication details
Přínos ERG v časné diagnostice chlorochinové a hydroxychlorochinové makulopatie
| Title in English | The ERG Contribution in Early Diagnosis of Chloroquine and Hydroxychloroquine Maculopathy |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Česká a Slovenská Oftalmologie |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | ERG, antimalarica, drug cumulative maculopathy |
| Description | Derivates of chloroquine (Plaquenil, Delagil) used for long-term treatment of rheumatic diseases may cause clinically proven irreversible maculopathy, which may progress even after the discontinuation of their application. The optimal early diagnosis of ocular toxicity of chloroquine or hydroxychloroquine drug remains controversial up to now. The aim of this review paper was to evaluate how appropriate is the indication of the electroretinographic (ERG) examination due to early diagnosis of cumulative drug-related maculopathy. Photopic, pattern and multifocal ERG were examinated in 10 patients (20 eyes) treated by means of antimalarics, 9 due to the rheumatoid arthritis (RA) and 1 due to the systemic lupus erythemathodes (SLE). The control group consisted of 12 healthy (20 eyes)age matched patients.The significant difference between the group treated with chloroquine or hydroxychloroquine and the control group at the 1% level of significance was found in the photopic ERG the value of the b wave latency, in pattern ERG, the values of the waves N35-P50 and P50-N95 amplitudes, and at the 5% level of significance in photopic ERG, the wave a amplitude value and in multifocal ERG, the value of the P1 a N1 parts latency in the pericentral ring. It follows from the results, that the ERG examination is suitable for the early diagnosis drug cumulative maculopathy caused by chloroquine derivates. |