Publication details
Graft vs host disease jako neobvyklá komplikace po transplantaci jater
| Title in English | Graft-versus-host disease as an unusual complication following liver transplant |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Gastroenterologie a hepatologie |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | exanthem; graft-versus-host disease; liver transplant |
| Description | The autors describe the case of a 59-year-old woman who underwent liver transplant due to secondary biliary cirrhosis following iatrogenic damage of the ductus choledochus. The patient developed skin exanthem accompanied by diarrhoea, followed by leukopenia and septic shock. The GVHD diagnosis was established by skin biopsy and supported by determining the chimerism. The treatment involved high doses of glucocorticoids maintaining the lowest possible effective levels of tacrolimus, immunoglobulins, anti-CD25 mAbs, and symptomatic therapy (factor stimulating granulocytes, antibiotics and antivirotics). The patient is now 10 months after the liver transplant without any GVHD clinical symptoms and with good functioning of the liver graft. |