Publication details
Úloha kouření v epigenetické modifikaci fenotypu: nejnovější poznatky o patologických procesech vyvolaných kouřením
| Title in English | The role of amoking in the epigenetic modification of phenotype: the latest knowledge about smoking induced pathways |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Časopis lékařů Českých |
| MU Faculty or unit | |
| Citation | |
| Field | Hygiene |
| Keywords | genes; smoking; epigenetic pathways; foetal programming |
| Description | Many environmental factors, including chemicals in cigarette smoke, have deleterious effects on health. Prenatal exposure to maternal smoking is associated with foetal disturbed development, and also with an increased risk of serious diseases during childhood and adulthood. The possible pathways of abberant foetal programming are the interactions of genes and environmental factors through epigenetic mechanisms. Some models of altered epigenetic regulations were described: DNA methylation, non coding RNA mediated gene regulation and histone modification. Both active and passive smoking can induce changes in all studied epigenetic pathways and can even be transmitted to future generation. |