Publication details
The fibroblast growth factors in multiple myeloma
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Leukemia |
| MU Faculty or unit | |
| Citation | |
| web | fulltext |
| Doi | http://dx.doi.org/10.1038/sj.leu.2404202 |
| Field | Physiology |
| Keywords | FACTOR RECEPTOR-3; EXPRESSION; MUTATIONS |
| Description | Fibroblast growth factor receptor 3 (FGFR3) is a membrane-anchored receptor tyrosine kinase that transmits intercellular signals mediated by a family of fibroblast growth factors (FGFs). In multiple myeloma (MM), 15% of patients markedly upregulate FGFR3 as a consequence of a t(4;14)(p16.3;q32) translocation. Ectopic expression of FGFR3 enhances MM cell proliferation and survival, demonstrating the oncogenic potential of FGFR3. |