Informace o publikaci
The fibroblast growth factors in multiple myeloma
| Autoři | |
|---|---|
| Rok publikování | 2006 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Leukemia |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | fulltext |
| Doi | http://dx.doi.org/10.1038/sj.leu.2404202 |
| Obor | Fyziologie |
| Klíčová slova | FACTOR RECEPTOR-3; EXPRESSION; MUTATIONS |
| Popis | Fibroblast growth factor receptor 3 (FGFR3) is a membrane-anchored receptor tyrosine kinase that transmits intercellular signals mediated by a family of fibroblast growth factors (FGFs). In multiple myeloma (MM), 15% of patients markedly upregulate FGFR3 as a consequence of a t(4;14)(p16.3;q32) translocation. Ectopic expression of FGFR3 enhances MM cell proliferation and survival, demonstrating the oncogenic potential of FGFR3. |