Publication details
Electroanalytical Methods – Sensitive Tools for DNA Structure Transitions Analysis
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Proceedings |
| Conference | XXXIII. Moderní elektrochemické metody, sborník přednášek |
| MU Faculty or unit | |
| Citation | |
| Field | Electrochemistry |
| Keywords | DNA structure transitions;DNA secondary structures;G-quadruplex;electroanalytical methods;mercury electrodes;carbon electrodes |
| Description | Nucleic acids, depending on their nucleotide sequences, can exhibit a variety of conformational transitions and adopt different secondary structures such as hairpins, triplexes, left-handed Z-DNA or quadruplexes. Nucleic acids are electroactive species producing a set of intrinsic voltammetric signals at different types of working electrodes. Some of these are sensitive to DNA structure changes. In this contribution we studied the influence of the formation of G-quadruplexes on the electrochemical behavior of synthetic ODN at mercury and carbon electrodes. |