Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach

• Authors: DWYER Michael P.; KEERTIKAR Kartick; PARUCH Kamil; ALVAREZ Carmen; LABROLI Marc; POKER Cory; FISHMANN Thierry O.; MAYER-EZEL Rosemary; BOND Richard; WANG Yan; AZEVEDO Rita; GUZI Timothy J.
• Year of publication: 2013
• Type: Article in Periodical
• Magazine / Source: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
• MU Faculty or unit: Faculty of Science
• Doi: http://dx.doi.org/10.1016/j.bmcl.2013.08.110
• Field: Genetics and molecular biology
• Keywords: Pan–Pim kinase pyrazolo[1,5-a]pyrimidine
• Description: The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan–Pim inhibitors such as 11j are described.