Publication details
Incidence of thromboembolic complications in patients with atrial fibrilation in anamnesis depending on the anticoagulant/antiplatelet therapy
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| Year of publication | 2013 |
| Type | Conference abstract |
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| Description | The atrial fibrilation represents one of the most common clinically indicated disorders of the cardiac dysrhythmia. Its increasing incidents correlates with increasing polymorbidity, age and sex of the patients. Nowadays, the number of patients in Czech Republic counts around 1 % of the total Czech Republic population. A prevention of arterial complications represents an important aspect in treating the possible future worsening of a patient health state. The treatment is normally based on the anticoagulant or antiaggregant therapy. The sample size involved 66 patients cured for six months in the Second Department of Surgery, St. Anne’s University Hospital, Brno. Patients indicated with the increased risk of the arterial fibrillation were distributed into five groups (four groups according to the farmacotherapy of the blood coagulation and one more group of patients for whom the anticoagulant/antiaggregant therapy has not been indicated). A correlation between all the five groups has been investigated with respect to the applied therapy and the incidence of the thromboembolic events. In the full investigated ensemble of patients, the thromboembolic complications were indicated for 23 persons. In the group treated with warfarin, which in total involved 23 patients, seven persons were diagnosed with the arterial complications what represents 30.4%. In the second group, which in total included 29 persons treated with antiaggregation therapy by means of acetylsalicylic acid were 9 patients diagnosed with the thromboembolic complication. In this group, the relative number of impacts represents 31%. Finally, it has been found that in the group with no anti-coagulant therapy the risk of the thromboembolic events increased up to 70%. The obtained results suggest that the risk of the complications is similar in both groups treated by either warfarin or acetylsalicylic acid, which are both common drugs applied in the situations where blood coagulation is an issue. While in the most cases that, in spite of the warfarintreatment, lead to the complications, the reason of the unsuccessful therapy could be associated with the nonoptimal level of INR. Moreover, we cannot also exclude a high rate of the drug therapy interactions as a reason of the anticoagulant or antiaggregant failure. |