Publication details
Tumoriformní varianta roztroušené sklerózy - dvě kazuistiky
| Title in English | Tumefactive Variant of Multiple Sclerosis - Two Case Reports |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | multiple sclerosis; tumefactive multiple sclerosis; magnetic resonance imaging; positron emission tomography; stereo-tactic brain biopsy |
| Attached files | |
| Description | Diagnosis of multiple sclerosis (MS) according to the revised diagnostic criteria is mostly based on clinical symptoms and magnetic resonance imaging (MRI). Diagnosis of MS requires elimination of more likely diagnoses. Multiple sclerosis plaques on MRI generally appear as T2 hyper-signal lesions in at least two out of four areas of the central nervous system CNS: periventriular, juxtacortical, infratentorial or spinal cord. Tumefactive MS (TMS) is a rare variant of this disease with the estimated prevalence of about 3 cases per million people. Its radiological and clinical symptoms are different from common MS variants and could mimic other diseases such as brain tumors or inflammatory diseases. Typical radiographic feature of TMS is defined as a solitary large lesion with the size of >2cm, associated with perilesional oedema and/or the presence of ring enhancement on MR. Clinical signs and symptoms are dependent on lesion location and size, and include headache, cognitive abnormalities, mental confusion, aphasia, apraxia and/or seizures. The clinical presentation and MRI appearance of these lesions often require brain biopsy. Diagnosis could be supported by positron emission tomography, cerebrospinal fluid examination and evoked potentials. In our report we present two patients with tumefactive MS. The purpose of this report is to emphasize clinical and radiological features of this rare disease and to pinpoint examination procedures that could be used in differential diagnosis. |