MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer.

• Authors: HÉŽOVÁ Renata; KOVAŘÍKOVÁ Alena; SROVNAL Josef; ZEMANOVÁ Milada; HARUŠTIAK Tomáš; EHRMANN Jiří; HAJDÚCH Marian; FABIAN Pavel; ŠACHLOVÁ Milana; SLABÝ Ondřej
• Year of publication: 2014
• Type: Conference abstract
• MU Faculty or unit: Central European Institute of Technology
• Description: Esophageal cancer is disease with very poor prognosis. There are two main types of esophageal carcinoma: adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). The aim of this study is to identify potential microRNA (miRNA) as biomarkers of esophageal cancer.Our results indicate a significantly decreased expression of miR-205 in EAC patients (n=22) in comparison with adjacent mucosa and significantly decreased expression of miR-205 in EAC patients in comparison with ESSC (n=22).Increased level of miR-205 is associated with a significantly better overall survival of EAC patients. Experimentally decreased level of anti-miR-205 in ESCC cell line was significantly affecting cell proliferation, migration and anchorage independent growth. Conversely, experimental increase of miR-205 in EAC cell line leads to decrease in cell proliferation and cell migration. This study may suggest the possibility of using miR-205 as biomarker for more reliable diagnosis of esophageal cancer and distinguishing of EAC from ESCC.

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