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Informace o publikaci
MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer.
Autoři | |
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Rok publikování | 2014 |
Druh | Konferenční abstrakty |
Fakulta / Pracoviště MU | |
Citace | |
Popis | Esophageal cancer is disease with very poor prognosis. There are two main types of esophageal carcinoma: adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). The aim of this study is to identify potential microRNA (miRNA) as biomarkers of esophageal cancer.Our results indicate a significantly decreased expression of miR-205 in EAC patients (n=22) in comparison with adjacent mucosa and significantly decreased expression of miR-205 in EAC patients in comparison with ESSC (n=22).Increased level of miR-205 is associated with a significantly better overall survival of EAC patients. Experimentally decreased level of anti-miR-205 in ESCC cell line was significantly affecting cell proliferation, migration and anchorage independent growth. Conversely, experimental increase of miR-205 in EAC cell line leads to decrease in cell proliferation and cell migration. This study may suggest the possibility of using miR-205 as biomarker for more reliable diagnosis of esophageal cancer and distinguishing of EAC from ESCC. |
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