Publication details
Kombinační imunosupresivní léčba
| Title in English | Combination immunosuppressant therapy |
|---|---|
| Authors | |
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Kardiologická revue - Interní medicína |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | immunosuppression; heart transplantation; combination therapy |
| Description | In recent years heart transplantation has become an established treatment method for patients with severe heart failure. This treatment involves life-long immunosuppressant therapy with a combination of drugs. Classical immunosuppression is achieved with cyclosporine or tacrolimus, mycophenolate mofetil and corticosteroids. In the last few years, new regimes of immunosuppressive drugs have been used in post-heart transplant patients suffering from renal dysfunction or allograft vasculopathy: a combination of low doses of calcineurin inhibitors with low doses of mTOR inhibitors or calcineurin-free regimes, which are not so nephrotoxic There has been an effort to withdraw corticosteroids from all regimes after the first year and to have life-long therapy based on a combination of two drugs. Combination therapy is tailored according to the patient's comorbidities. |