Publication details
Farmakogenetika v onkologii
| Title in English | Pharmacogenetics in oncology |
|---|---|
| Authors | |
| Year of publication | 2014 |
| Type | Chapter of a book |
| MU Faculty or unit | |
| Citation | |
| Description | Pharmacogenomics is a subdiscipline within the field of personalized medicine the goal of which is to find an association between variability in drug response and genome-wide variability and/or transcription of gene-encoded information. Optimally, pharmacogenetic testing is indicated prior to initiation of treatment with selected drugs and is aimed at increasing efficacy or reducing the risks of developing toxicity in predisposed patients. This chapter provides examples from the field of anticancer therapy, on the key enzymes involved in the metabolization of selected antitumor drugs -cytochrome P450 and his isoenzymes, dihydropyrimidine dehydrogenase, uridine diphosphate glucuronosyltransferase, N-acetyltransferase and thiopurine S-methyltransferase. In accordance with the requirements of evidence-based medicine, these strategies should be utilized whenever evidence supporting their use is available, what means for most drugs future testing at prospective clinical trials. |