Publication details
Bipolární porucha - minimum pro farmaceuty
| Title in English | Bipolar disorder - a minimum for pharmacists |
|---|---|
| Authors | |
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Praktické lékárenství |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.praktickelekarenstvi.cz/artkey/lek-201502-0005_Bipolarni_porucha_8211_minimum_pro_farmaceuty.php |
| Field | Psychiatry, sexuology |
| Keywords | bipolar disorder; neurobiology; the recommended treatment procedures; lithium |
| Description | Bipolar disorder (BD) is a severe, mainly reccurent, multifactorial mental illness. Ĺithium with its antimanic, antidepressive, antisuicidal, prophylactic and neuroprotective properties has remained a major treatment of BD. In acute mania lithium, valproate, and several atypical antipsychotics in the monotherapy or combination with mood stabilizers are first-line treatments. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, as well as olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or valproate plus SSRI/bupropion remain first-line options. Still, the use of antidepressants is controversial. For maintenance treatment the choice between given possibilities is guided by the first phase or prevailing phases in long-term course. The tolerability and safety are becoming very important issues. New therapeutic possibility will be given by understanding of neurobiology. |