Publication details
Intersticiální plicní procesy a granulomatózy asociované s běžným variabilním imunodeficitem
| Title in English | Interstitial lung diseases and granulomatoses associated common variable immunodeficiency |
|---|---|
| Authors | |
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Pneumology |
| Keywords | common variable immunodeficiency; granulomatosis; interstitial lung fibrosis |
| Description | Common variable immunodeficiency disorder belongs to the most common primary human immunodeficiencies and it is characterized by primary defective immunoglobulin production. Hypogammaglobulinemia manifests in every age, usually in adult people. There is no gender predisposition. The prevalence is 1 :25 000-1 :50 000. The ethiopathogenesisofthe majority of CVIDs is unknown.The main clinical respiratory symptoms include recurrent respiratory infects, especially bacterial etiology, sinusitis, bronchitis, pneumonia, leading to bronchiectasis and lung fibrosis. Interstitial lung fibrosis and granulomatosis often manifest at diagnosis of CVID and they are negative prognostic factors of the disease. |