Publication details

Can Rituximab Improve the Outcome of Patients with Nodular Lymphocyte-Predominant Hodgkin's Lymphoma?

Authors

MÓCIKOVÁ Heidi PYTLIK Robert STEPANKOVA Pavla MICHALKA Jozef MARKOVA Jana KOREN Jan BURESOVA Lucie RAIDA Ludek KRÁL Zdeněk

Year of publication 2015
Type Article in Periodical
Magazine / Source Acta Haematologica
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1159/000381327
Field Oncology and hematology
Keywords Chemotherapy; Hodgkin's lymphoma; Nodular lymphocyte-predominant Hodgkin's lymphoma; Rituximab
Description Background: Nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) is a rare subtype of Hodgkin's lymphoma showing strong CD20 expression. The role of rituximab in treating NLPHL still needs clarification. Methods: We retrospectively reviewed the outcome of 23 patients with NLPHL treated with rituximab alone or in combination with chemotherapy and/or radiotherapy as part of their first-or second-line treatment. Results: The median follow-up of the whole group was 67 months, and all patients remained alive. Twenty-two patients achieved complete remission after rituximab-based therapy, and one of them relapsed 32 months after treatment. One patient treated with rituximab alone achieved partial remission and progressed 22 months after treatment. Conclusion: The prognosis of NLPHL is excellent. Rituximab combined with chemotherapy and/or radiotherapy appears to prevent disease progression/relapse.

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