Publication details

L1CAM expression in endometrial carcinomas: an ENITEC collaboration study

Authors	PUTTEN L.J.M. van der VISSER Nicole C. M. VIJVER Koen SANTACANA Maria BRONSERT Peter BULTEN Johan HIRSCHFELD Marc COLAS Eva GIL-MORENO Antonio GARCIA Angel MANCEBO Gemma ALAMEDA Fransesc TROVIK Jone KOPPERUD Reidun K. HUVILA Jutta SCHRAUWEN Stefanie KOSKAS Martin WALKER Francine WEINBERGER Vít MINÁŘ Luboš JANDAKOVA Eva SNIJDERS Marc P. L. M. VAN DEN BERG-VAN ERP Saskia MATIAS-GUIU Xavier SALVESEN Helga B. AMANT Frederic MASSUGER Leon F. A. G. PIJNENBORG Johanna M. A.
Year of publication	2016
Type	Article in Periodical
Magazine / Source	British journal of cancer
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1038/bjc.2016.235
Field	Oncology and hematology
Keywords	endometrial cancer; endometrioid; non-endometrioid; L1CAM; immunohistochemistry
Description	Background: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas. Methods: The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated. Results: In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs. Conclusions: The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.