Publication details

Antifosfolipidový syndrom – klinické projevy, diagnostika a možnosti léčby, komplikace

Title in English Antiphospholipid syndrome - clinical manifestations, evaluation, therapeutic options, complications
Authors

BULIKOVÁ Alena

Year of publication 2016
Type Article in Periodical
Magazine / Source Remedia
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords antiphospholipid syndrome; clinical manifestation; diagnosis; treatment; complications
Description Antiphospholipid syndrome represents one of the most important thrombophilic conditions. It is defined by simultaneous presence of clinical manifestation, i.e. thrombosis or reproductive failure, and detection of antiphospholipid antibodies. Nevertheless, it can be also accompanied by wide spectrum of so called non-criteria manifestations like heart valve disease, nephropathy, thrombocytopenia, skin involvement, and others. Diagnosis of the antiphospholipid syndrome is confirmed by fulfilling of diagnostic criteria, which are defined by international consensus. The main therapeutic approach is the antithrombotic treatment. However, immunomodulatory drugs can play an important role in some situations, especially in non-criteria manifestations. The most serious complication of this syndrome is catastrophic antiphospholipid syndrome. This life treating condition should be kept in mind in patients with antiphospholipid antibodies, as it needs early diagnosis and intensive treatment.

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