Publication details
Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | Carbohydrate Research |
| MU Faculty or unit | |
| Citation | |
| web | https://www.sciencedirect.com/science/article/pii/S0008621516303160?via%3Dihub |
| Doi | https://doi.org/10.1016/j.carres.2016.11.008 |
| Field | Biochemistry |
| Keywords | Burkholderia cenocepacia; Mannose-binding lectin; Glycoclusters; Click reaction; Anti-adhesion therapy |
| Description | The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. The interaction between the glycoclusters and the mannose binding BC2L-A lectin from B. cenocepacia was examined by isothermal microcalorimetry, surface plasmon resonance, inhibition of yeast agglutination and analytical ultracentrifugation. |
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