Publication details
Anion-pi interactions in flavoproteins involve a substantial charge-transfer component
Authors | |
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Year of publication | 2017 |
Type | Article in Periodical |
Magazine / Source | Chemistry - A European Journal |
MU Faculty or unit | |
Citation | |
Web | DOI: 10.1002/chem.201605307 |
Doi | http://dx.doi.org/10.1002/chem.201605307 |
Field | Physical chemistry and theoretical chemistry |
Keywords | covalence; charge-transfer component; energy decomposition |
Attached files | |
Description | Anion-pi interactions have been shown to stabilize flavoproteins and to regulate the redox potential of the flavin cofactor. They are commonly attributed to electrostatic forces. Here we show that anion-flavin interactions have a substantial charge-transfer component. Our conclusion emanates from a multiapproach theoretical analysis and is backed by previously reported observations of absorption bands, originating from charge transfer between oxidized flavin and proximate cystein thiolate groups. This partial covalency of anion-flavin contacts renders classical simulations of flavoproteins questionable. |
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