Publication details
Enantioselective Synthesis of Cephalimysins B and C
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Organic Letters |
| MU Faculty or unit | |
| Citation | |
| web | Full Text |
| Doi | http://dx.doi.org/10.1021/acs.orglett.6b03373 |
| Field | Organic chemistry |
| Keywords | ASYMMETRIC TOTAL-SYNTHESIS; PSEUROTIN-A; ABSOLUTE-CONFIGURATION; 1.3-DICARBONYL COMPOUNDS; ANGIOGENESIS INHIBITOR; ASPERGILLUS-FUMIGATUS; MICHAEL ADDITIONS; HYPEROLACTONE-C; AZASPIRENE; PRODUCT |
| Description | The first synthesis of cephalimysins B and C is reported. The route features a Ni(II)-diamine-catalyzed enantioselective conjugate addition of a densely substituted 3(2H)-furanone and an efficient dihydroxylation-lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation. |
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