Publication details
Systolická hypertenze a pulsní tlak - kardiovaskulární riziko a současné možnosti léčby
| Title in English | Systolic hypertension and pulse pressure - cardiovascular risk and current treatment options |
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| Authors | |
| Year of publication | 2017 |
| Type | Popularization text |
| MU Faculty or unit | |
| Citation | |
| Description | In people older than 55 years, systolic and pulse pressures provide a stronger prediction value for cardiovascular risk than diastolic pressure. Increased systolic and pulse pressures are due to decreased compliance of elastic arteries. These are in turn the result of endothelial dysfunction, atherosclerosis and decreasing number of elastic fibres in the arterial walls. Increased systolic and pulse pressure values are more common in obese individuals, elderly patients, smokers, patients with diabetes and patients with atherogenic dyslipidaemia. Target systolic pressure value in the general population is less than 140 mm Hg, and less than 150 mm Hg in very old individuals (older than 80 years). Target values of pulse pressure have not been exactly specified yet. it is assumed that those with pulse pressure below 50 mm Hg are at lesser risk, while individuals with pulse pressure above 65 mm Hg should be at high risk. Systolic and pulse pressures may be best reduced using a combination of renin-angiotensin system blockers with low doses of a diuretic, optimally indapamide, and/or the calcium channel blocker dihydropyridine. Fixed drug combinations are recommended. |