ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data

• Authors: BYSTRÝ Vojtěch; REIGL Tomáš; KREJČÍ Adam; DEMKO Martin; HANÁKOVÁ Barbora; GRIONI Andrea; KNECHT Henrik; SCHLITT Max; DREGER Peter; SELLNER Leopold; HERRMANN Dietrich; PINGEON Marine; BOUDJOGHRA Myriam; RIJNTJES Jos; POTT Christiane; LANGERAK Anton W.; GROENEN Patricia J. T. A.; DAVI Frederic; BRUGGEMANN Monika; DARZENTAS Nikos
• Year of publication: 2017
• Type: Article in Periodical
• Magazine / Source: Bioinformatics
• MU Faculty or unit: Central European Institute of Technology
• web: https://academic.oup.com/bioinformatics/article-abstract/33/3/435/2580414/ARResT-Interrogate-an-interactive-immunoprofiler?redirectedFrom=fulltext
• Doi: http://dx.doi.org/10.1093/bioinformatics/btw634
• Field: Biochemistry
• Keywords: REPERTOIRE
• Description: Motivation: The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. Results: We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations.

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