Publication details
Aspekty vývoje vakcíny proti Lymeské borrelióze ve veterinárním i humánním lékařství – přehled a kandidátní vakcíny
| Title in English | Aspects of Lyme borreliosis vaccine development in both veterinary and human medicine – a review and vaccine candidates |
|---|---|
| Authors | |
| Year of publication | 2017 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | The most effective measure to prevent the spread of dangerous diseases is vaccination. The prevention of Lyme borreliosis, a tick-borne zoonosis, consists currently only of the individual avoidance of risk areas and the use of repellents due to the unavailability of the human vaccine. The development of Lyme borreliosis is still alive despite the initial commercial failure of the first available human vaccine, as evidenced by the availability of several functional and safe veterinary vaccines for pets. Potential targets include the antigenic structures of the spirochaete Borrelia burgdorferi sensu lato, etiologic agent of borreliosis, such as outer surface lipoprotein A or C, adhesive proteins, or surface glycolipids. Perspective is the use of recombinant multivalent vaccines for protection against a wide range of European and North American borreliae. An interesting strategy for controlling and disrupting the enzootic cycle of borreliae is the oral vaccination of reservoir hosts, which could lead to a decrease in ticks' positivity. The use of tick proteins, important for transmission of pathogens, reproduction or development, for the preparation of vaccine is a promising strategy that has the potential to provide protection against several pathogenic microorganisms at once. méně |