Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis

• Authors: SCHMIDT T.; HOCH M.; LOFTI JAD S.S.; SOLIMANI F.; DI ZENZO G.; MARZANO A.V.; GOEBELER M.; COZZANI E.; KERN J.S.; SITARU C.; LAKOŠ JUKIĆ I.; SÁRDY M.; UZUN S.; JEDLIČKOVÁ Hana; GLÄSER R.; KANEDA M.; EMING R.; GÖPEL G.; ISHII N.; GREENE B.; HASHIMOTO T.; HERTL M.
• Year of publication: 2017
• Type: Article in Periodical
• Magazine / Source: British Journal of Dermatology
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/bjd.15800
• Field: Dermatovenerology
• Keywords: Epidermolysis bullosa acquisita
• Description: Epidermolysis bullosa acquisita (EBA) is a rare, potentially devastating autoimmune disease of the skin. IgG autoantibodies directed against type VII collagen (Col7), the major component of anchoring fibrils, induce skin fragility leading to cutaneous and mucocutaneous blister formation, which is mostly of a scarring phenotype. Thus, powerful and reproducible diagnostic assays are critical to establish the diagnosis of EBA early to avoid irreversible sequelae.