Publication details

hIAPP forms toxic oligomers in plasma

Authors

CAMARGO D.C.R. GARG D. BUDAY K. FRANKO A. CAMARGO A.R. SCHMIDT F. COX S.J. SULADZE S. HASLBECK M. MIDEKSA Y.G. GEMMECKER G. AICHLER M. METTENLEITER G. SCHULZ M. WALCH A.K. DE ANGELIS M.H. FEIGE M.J. SIERRA C.A. CONRAD M. TRIPSIANES Konstantinos RAMAMOORTHY A. REIF B.

Year of publication 2018
Type Article in Periodical
Magazine / Source Chemical communications
MU Faculty or unit

Central European Institute of Technology

Citation
Doi http://dx.doi.org/10.1039/c8cc03097a
Keywords ISLET AMYLOID POLYPEPTIDE; INTRINSIC FLUORESCENCE; DIABETES-MELLITUS; TRANSGENIC MICE; INSULIN; AMYLIN; BETA; AGGREGATION; MECHANISM; FIBRILS
Description In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in -sheet rich oligomers with increased -cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
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