hIAPP forms toxic oligomers in plasma

• Authors: CAMARGO D.C.R.; GARG D.; BUDAY K.; FRANKO A.; CAMARGO A.R.; SCHMIDT F.; COX S.J.; SULADZE S.; HASLBECK M.; MIDEKSA Y.G.; GEMMECKER G.; AICHLER M.; METTENLEITER G.; SCHULZ M.; WALCH A.K.; DE ANGELIS M.H.; FEIGE M.J.; SIERRA C.A.; CONRAD M.; TRIPSIANES Konstantinos; RAMAMOORTHY A.; REIF B.
• Year of publication: 2018
• Type: Article in Periodical
• Magazine / Source: Chemical communications
• MU Faculty or unit: Central European Institute of Technology
• Doi: https://doi.org/10.1039/c8cc03097a
• Keywords: ISLET AMYLOID POLYPEPTIDE; INTRINSIC FLUORESCENCE; DIABETES-MELLITUS; TRANSGENIC MICE; INSULIN; AMYLIN; BETA; AGGREGATION; MECHANISM; FIBRILS
• Description: In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in -sheet rich oligomers with increased -cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

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