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Informace o publikaci
hIAPP forms toxic oligomers in plasma
Autoři | |
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Rok publikování | 2018 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Chemical communications |
Fakulta / Pracoviště MU | |
Citace | |
Doi | http://dx.doi.org/10.1039/c8cc03097a |
Klíčová slova | ISLET AMYLOID POLYPEPTIDE; INTRINSIC FLUORESCENCE; DIABETES-MELLITUS; TRANSGENIC MICE; INSULIN; AMYLIN; BETA; AGGREGATION; MECHANISM; FIBRILS |
Popis | In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in -sheet rich oligomers with increased -cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases. |
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