HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

• Authors: JANECKOVA Lucie; KOLAR Michal; SVEC Jiri; LANIKOVA Lucie; POSPÍCHALOVÁ Vendula; BALOGHOVA Nikol; VOJTECHOVA Martina; SLONCOVA Eva; STRNAD Hynek; KORINEK Vladimir
• Year of publication: 2016
• Type: Article in Periodical
• Magazine / Source: TRANSLATIONAL ONCOLOGY
• MU Faculty or unit: Faculty of Science
• Web: Full Text
• Doi: http://dx.doi.org/10.1016/j.tranon.2016.01.005
• Keywords: Apoptosis; Bnip3L; caspase-12; hair follicles; PCR arrays
• Description: Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.