Publication details
Stabilized antioxidative plant extracts formulated by liquisolid technique
| Authors | |
|---|---|
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.sciencedirect.com/science/article/pii/S1773224720313113 |
| Doi | http://dx.doi.org/10.1016/j.jddst.2020.102022 |
| Keywords | Neusilin (R); Antioxidant activity; Liquisolid system; Liquid plant extract; Drying process; Partial least squares |
| Description | Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract. |