Publication details

Ložiskové léze kostí - diagnostické využití imunohistochemie a molekulární patologie

Title in English Bone lesions - diagnostic approach using immunohistochemistry and molecular pathology
Authors

STANICZKOVÁ ZAMBO Iva SHATOKHINA Tetiana

Year of publication 2021
Type Article in Periodical
Magazine / Source Česko-slovenská patologie
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.prolekare.cz/casopisy/cesko-slovenska-patologie/2021-1-15/loziskove-leze-kosti-diagnosticke-vyuziti-imunohistochemie-a-molekularni-patologie-126467
Keywords odvápnění; imunohistochemie; molekulární patologie; kulatobuněčné tumory; kostní metastázy; primární kostní lymfomy
Description Immunohistochemistry and molecular pathology play an essential role in the diagnosis of some focal bone lesions. These techniques may greatly help to distinguish primary bone tumors from metastatic diseases and allow a biologically important refinements in subclassification of round cell sarcomas. Recently, the diagnostic accuracy of organ and tumor specific antibodies has improved significantly. Knowledge of new type of antibodies and their meaningful use enables an accurate classification of the most undifferentiated carcinomas of unknown primary. However, the interpretation of immunohistochemical stains and molecular genetic analysis can be difficult in bone biopsies due to previous decalcification. This article summarizes the most important algorithmic approach to the diagnosis of bone tumors. It outlines the most frequently used tissue-specific antibodies. New advances in the understanding of bone tumorigenesis are also discussed.

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