Publication details
Evaluation of the stability of biologically active chlorinated arylcarbamoylnaphthalenylcarbamates by RP-HPLC
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Proceedings |
| Conference | Proceedings of the 18th International Students Conference “Modern Analytical Chemistry” |
| MU Faculty or unit | |
| Citation | |
| Web | http://web.natur.cuni.cz/analchem/isc/isc18.pdf |
| Keywords | carbamates; HPLC; phenyl-based stationary phases; stability |
| Description | The original carbamates with excellent antimicrobial activity derived from 1-hydroxy-N-(2,4,5-trichlorophenyl)-2-naphthamide were investigated for their stability. 2-[N-(2,4,5-Trichlorophenyl)- carbamoyl]naphthalen-1-yl ethyl carbamate with the weakest steric protection, i.e., with the expected highest degradability and two other carbamates with a more sterically protected carbamate bond (2-[N-(2,4,5-trichlorophenyl)carbamoyl]naphthalen-1-yl 2-phenylethyl carbamate and 2-[N-(2,4,5-trichlorophenyl)carbamoyl]- naphthalen-1-yl isopropyl carbamate), i.e., with the expected lower degradability, were chosen. The developed HPLC methods using chromatographic columns with phenyl-based stationary phases and acetonitrile:phosphate buffer (pH = 2.5) as the mobile phases provided sufficient resolution between the studied carbamates and expected degradant, pattern anilide. |