In vivo and in vitro effects of salidroside on liver cytochrome P450

• Authors: KLÁSKOVÁ Eva; JUŘICA Jan; HAMMER Tomáš; MÁCHALOVÁ Alena; MLČŮCHOVÁ Natálie; VYKLICKÁ Kateřina; BRENEROVÁ Petra; BOŘILOVÁ LINHARTOVÁ Petra; ZENDULKA Ondřej
• Year of publication: 2022
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms.

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