Publication details
RHEOLOGICAL EVALUATION OF THERMOSENSITIVE HYDROGELS AS IN SITU FORMING GELS FOR OROMUCOSAL USE
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Proceedings |
| Conference | 26th Conference of Slovak physicists : Proceedings |
| MU Faculty or unit | |
| Citation | |
| Keywords | rheological evaluation; thermosensitive; hydrogel; in situ gel; oromucosal delivery; poloxamer; methylcellulose |
| Attached files | |
| Description | The study focuses on the rheological evaluation of thermosensitive in situ gels containing poloxamer and/or methylcellulose and other additives. Gel structure formation and a satisfactory increase in viscosity were detected rheologically only in combinations with poloxamer 407. It can be concluded that methylcellulose can be used as a constitutive excipient in combination with poloxamer 407. Methylcellulose can be widely used in concentrations less than 1% as a viscosity-increasing agent for oromucosal in situ gels. |