Informace o publikaci
RHEOLOGICAL EVALUATION OF THERMOSENSITIVE HYDROGELS AS IN SITU FORMING GELS FOR OROMUCOSAL USE
| Autoři | |
|---|---|
| Rok publikování | 2022 |
| Druh | Článek ve sborníku |
| Konference | 26th Conference of Slovak physicists : Proceedings |
| Fakulta / Pracoviště MU | |
| Citace | |
| Klíčová slova | rheological evaluation; thermosensitive; hydrogel; in situ gel; oromucosal delivery; poloxamer; methylcellulose |
| Přiložené soubory | |
| Popis | The study focuses on the rheological evaluation of thermosensitive in situ gels containing poloxamer and/or methylcellulose and other additives. Gel structure formation and a satisfactory increase in viscosity were detected rheologically only in combinations with poloxamer 407. It can be concluded that methylcellulose can be used as a constitutive excipient in combination with poloxamer 407. Methylcellulose can be widely used in concentrations less than 1% as a viscosity-increasing agent for oromucosal in situ gels. |