Publication details

Autoimmunity, cancer and COVID‑19 abnormally activate wound healing pathways: critical role of inflammation

Title in English Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation
Authors

GÁL Peter BRÁBEK Jan HOLUB Michal JAKOUBEK Milan ŠEDO Aleksi LACINA Lukáš STRNADOVÁ Karolina DUBOVÝ Petr HORNYCHOVÁ Helena RYŠKA Aleš SMETANA JR. Karel

Year of publication 2022
Type Article in Periodical
Magazine / Source Histochemistry and Cell Biology
MU Faculty or unit

Faculty of Medicine

Citation
Web https://link.springer.com/article/10.1007/s00418-022-02140-x
Doi http://dx.doi.org/10.1007/s00418-022-02140-x
Keywords Wound healing; Granulation tissue; Peripheral nerve injury; Rheumatoid arthritis; Cancer stroma; SARSCoV- 2; Myofibroblast; IL-6; Inflammation
Description Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe respiratory infections [e.g. coronavirus disease 2019 (COVID-19)] and wound healing, IL-6 plays a critical role in modulating the systemic and local microenvironment. Elevated serum levels of IL-6 interfere with the systemic immune response and are associated with disease progression and prognosis. As already noted, monoclonal antibodies blocking either IL-6 or binding of IL-6 to receptors have been used/tested successfully in the treatment of rheumatoid arthritis, many cancer types, and COVID-19. Therefore, in the present review, we compare the impact of IL-6 and anti-IL-6 therapy to demonstrate common (pathological) features of the studied diseases such as formation of granulation tissue with the presence of myofibroblasts and deposition of new extracellular matrix. We also discuss abnormal activation of other wound-healing-related pathways that have been implicated in autoimmune disorders, cancer or COVID-19.

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