Publication details
Intestinální selhání a syndrom krátkého střeva.
| Title in English | Intestinal failure and short bowel syndrome |
|---|---|
| Authors | |
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | Diabetologie - Metabolismus - Endokrinologie - Výživa |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.tigis.cz/casopisy/pro-lekare/diabetologie-metabolismus-endokrinologie-vyiva/itemlist/category/14-diabetologie-metabolismus-endokrinologie-vyziva |
| Keywords | glucagon like peptid-2; home parenteral nutrition; intestinal failure; intestinal transplantation; short bowel syndrome |
| Description | Short bowel syndrome is the main cause of chronic intestinal failure and represents a complex, from mild intestinal insufficiency that can be overcome with dietary and pharmacological treatment, to a severe condition required home parenteral nutrition support. Intestinal failure is defined as the reduction of gut function below the minimum necessary for the absorption of macronutrient and/ or water and electrolytes, such that intravenous supplementation is required to maintain health and growth. The severity of short bowel syndrome is related to its etiology, remnant small bowel length, underlying disease and bowel anatomy after resection. Long-term/ home parenteral nutrition is the vital and reference treatment for this condition that can lead to chronic complications in addition to a significantly low quality of life. However, GLP-2 treatment represents a new concept associated with parenteral nutrition reduction and in some cases even directed for weaning of PN. Intestinal rehabilitation surgery should be always proposed, that can restore digestive continuity and absorption. Intestinal transplantation/ multivisceral transplantation is reserved for patients with life threatening complications of long-term parenteral nutrition or untreatable abdominal diseases. |