Publication details
Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer
| Authors | |
|---|---|
| Year of publication | 2024 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | HORAK, Iryna, Tetiana SKATERNA, Olha HUDKOVA, Nely LATYSHKO, Olha KHUDIAKOVA, Kateryna TOKARCHUK, Iryna KRYSIUK, Teriana KISHKO, Lucia KNOPFOVÁ and Liudmyla DROBOT. Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer. In Current Issues od Biochemistry and Biotechnology 2024. 2024. ISSN 2410-776X. Available from: https://dx.doi.org/10.15407/biotech17.02.007. |
| Description | Using cellular models of breast, lung, and bone cancer, the effects of Ruk/CIN85 on multiple attributes of cancer cell plasticity were investigated. It was demonstrated that overexpression of Ruk/CIN85 resulted in elevated motility in vitro and metastatic potential in vivo, while Ruk/CIN85-knockdown cells are characterized by a lack of migration and metastasis. In addition, a high expression level of Ruk/CIN85 is necessary for the acquisition of resistance to anticancer drugs. Analysis of possible molecular mechanisms revealed expression of EMT- and CSCs-related markers, ECM remodeling ability, as well as metabolic reprogramming (Warburg effect) in Ruk/CIN85-overexpressing cells. On the contrary, Ruk/CIN85 knockdown resulted in the acquisition of a more differentiated phenotype with increased adhesion and proliferation. |
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