Publication details
High-throughput sequencing of Strongyloides stercoralis - a fatal disseminated infection in a dog
| Authors | |
|---|---|
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | Parasitology |
| MU Faculty or unit | |
| Citation | |
| Web | http://dx.doi.org/10.1017/S0031182024000568 |
| Doi | http://dx.doi.org/10.1017/S0031182024000568 |
| Keywords | dog; high-throughput sequencing; Strongyloides stercoralis; Strongyloidiasis; zoonotic |
| Description | The rhabditid nematode Strongyloides stercoralis is known worldwide as the causative agent of strongyloidiasis in humans. In addition to public health concerns, S. stercoralis also infects dogs, which represent a possible reservoir for potentially zoonotic transmissions. We describe the first confirmed case of fatal disseminated infection in a dog in the Czech Republic. The microscopic and histological results were supported by a complex genotyping approach. Using high-throughput sequencing of the hypervariable region (HVR-IV) of 18S rDNA and Sanger sequencing of the partial cytochrome c oxidase subunit 1 gene (cox1), the potentially zoonotic haplotype/lineage A of S. stercoralis was confirmed, while the solely canine haplotype/lineage B was not found. The development of the disease is mainly associated with immunodeficiency, and in this case, it was triggered by inappropriate treatment, in particular the use of corticosteroids. |
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