Publication details
Stereoselective synthesis of alpha-alkylidene- and substituted alkylidene-gamma-lactones
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Tetrahedron Letters |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.elsevier.nl/inca/publications/store/2/3/3/ |
| Field | Organic chemistry |
| Keywords | methylene lactones; coupling reactions; palladium; zinc compounds |
| Description | Cross-coupling reactions of (E)- and (Z)-tosylates of alpha-hydroxymethylene-gamma-butyrolactone with aryl, heteroaryl, alkyl, and alkynylzinc chlorides under Pd(PPh3)4 catalysis were found to be a suitable synthetic method for stereoselective preparation of alpha-alkylidene- and substituted alkylidene-gamma-lactones. Reactions, conducted under mild conditions, proceed with high stereoselectivity and moderate yields. |
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