Asociace psoriázy se dvěma genetickými polymorfismy v genu pro angiotenzinogen.

• Title in English: Association of Psoriasis with Angiotensinoge Gene Polymorphisms.
• Authors: VAŠKŮ Vladimír; VAŠKŮ Anna; IZAKOVIČOVÁ HOLLÁ Lydie; SEMRÁDOVÁ Věra
• Year of publication: 2000
• Type: Article in Periodical
• Magazine / Source: Česko-slovenská dermatologie
• MU Faculty or unit: Faculty of Medicine
• Field: Dermatovenerology
• Keywords: angiotensinogen; psoriasis; gene polymorphism
• Description: Angiotensinogen as an early phase protein can contribute to pathogenesis of psoriasis. The study evaluates two gene polymorphisms in the gene for angiotensinogen (M235T a A(-6)G ATG) in the group of 136 psoriatic patients and in 141 healthy subjects of comparable age and sex distribution.Both polymorphisms are in tight linkage disequilibrium in patients as well as in control subjects. Double genotype frequency significantly differs between psoriatic and healthy subjects (P=0.001).

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