Publication details
Některé genetické aspekty kožních T-lymfomů.
| Title in English | Some genetic aspects of cutaneous T-cell lymphomas |
|---|---|
| Authors | |
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Česko-slovenská dermatologie |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | ACE; TNF; cutaneous T-cell lymphoma; gene polymorphism |
| Description | The study was focused on an association between T-cell lymphoma and some supposed components of genetic background of the organism which could participate in the onset of cutaneous T-cell lymphomas. Polymorphisms of angiotensinogen I-converting enzyme (I/D ACE) and lymphotoxin alpha (NcoI TNF beta) genes were investigated in 33 Caucasian patients with cutaneous T-cell lymphomas and 66 healthy subjects using PCR methods and restriction enzyme analysis. In patients with T-Cell lymphoma, a concurrence of DD genotype of I/D ACE with B1 allele of TNF beta gene polymorphism was found(n=2/24, 8% in controls vs. n=8/18, 44% in CTCL, P=0.009, odds ratio=8.80, 95% confidence interval 1.50-51.50). The DD homozygote together with TNF beta heterozygote genotype (DDB1B2) was found to be the highest risk genotype for T-cell lymphoma patients (n=2/12, 17% in controls and 8/9, 89% in CTCL, P=0.002, odds ratio 40.00, 95% confidence interval 1.56-1024.12. |
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