Publication details

Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

Authors

BENEŠ Petr KAŇKOVÁ Kateřina MUŽÍK Jan GROCH Ladislav BENEDÍK Jaroslav ELBL Lubomír IZAKOVIČOVÁ HOLLÁ Lydie VAŠKŮ Anna ZNOJIL Vladimír VÁCHA Jiří

Year of publication 2001
Type Article in Periodical
Magazine / Source Molecular Genetics and Metabolism
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords gene; polymorphism; MTHFR; CAD; hypertension; diabetes
Description Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin.
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