Publication details
Caffeic acid affects an induced differentiation process into granulocyte stage in HL-60 myeloid leukaemia cell line
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Proceedings |
| Conference | Cells IV |
| MU Faculty or unit | |
| Citation | |
| Field | Morphological specializations and cytology |
| Keywords | induced differentiation; apoptosis; MTT-assay; HL-60 cell line; caffeic acid; retinoic acid; dimethyl sulfoxide |
| Description | The aim of presented study was to investigate possible effect of caffeic acid (CA) in combination with known differentiating agents, all-trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO) respectively, on the HL-60 human myeloid leukemia cell line. Treatment of the HL-60 cells by CA in combination with known differentiation inductors ATRA and DMSO leads to the reduction of cell viability and increased frequency of apoptosis. |
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