Publication details

Time- and Time-Frequency Analysis of Contractility and Desensitisation in Multicellular Heart Preparations

Title in English Time- and Time-frequency analysis of Contractility and Desensitisation in Multicellular Heart Preparations
Authors

NOVÁKOVÁ Marie PROVAZNÍK Ivo

Year of publication 2002
Type Article in Proceedings
Conference Proceedings of International Federation of Medical and Biological Engineering
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords cardiac contractility; side effects of neuroleptics; sigma receptor; wavelet analysis
Description The aim of this study was to examine the effect of sigma receptor ligand haloperidol in guinea pig atrial preparations. Stimulated contractions were recorded and analysed by time- and time-frequency methods. The analysis revealed that the compound exerts marked positive inotropic effect. This was significantly less pronounced in case of repeated drug administration. We conclude that sigma receptors in guinea pig atria undergo a desensitization process.

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